Fluorocholine F-18 Injection [F-18 FCH]

Fluorocholine F-18 Injection [F-18 FCH]

General Tracer Class Investigational Diagnostic PET Radiopharmaceutical Target Cellular membrane phospholipids, primarily in cancers Molecular Process Imaged Malignancy-induced overexpression of choline kinase (CK) Mechanism for in vivo retention Enters cell through choline transporters with accumulation in tumors in part due to malignancy-induced overexpression of choline kinase (CK) that catalyzes the phosphorylation of choline to form phosphorylcholine followed by generation of phosphatidylcholine in the tumor cell membrane / Metabolism FCH is cleared via the kidneys and excretion in the urine Recommended Activity and Allowable mass As FCH is investigational, there is no current standard for the amount of radiation to be administered. The kidney is the critical organ and limits administration levels of 18F-FCH to 4.07 MBq/kg (0.110 mCi/kg) in human research studies (DeGrado TR et al. J Nucl Med 2002) Dosimetry The effective dose equivalent (whole body) from administration of 4.07 MBq/kg (0.110 mCi/kg) is approximately 0.01 Sv for females and males. The dose-critical organ is the kidney, which receives 0.17 +/- 0.05 and 0.16 +/- 0.07 mSv/MBq (0.64 +/- 0.18 and 0.55 +/- 0.32 rad/mCi) for females and males.

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